PORPHYROMONAS GINGIVALIS - Dissertations.se
Alzheimers sjukdom - Behandling
Morphology can be short rod-shaped, or in broth culture, coccobacilli 0.5 µm by 1-2 µm in size. On solid media, colonies are generally smooth, shiny and convex. An enzyme called gingipains, which the Porphyromonas gingivalis (P. gingivalis) bacteria gives off, is the "main cause of Alzheimer's disease," Dr. Steve Dominy, study author and associate Gingipains, a class of P. gingivalis proteases, are found in association with neurons, tau tangles, and beta‐amyloid in specimens from the brains of individuals with AD. The brains of mice orally infected with P. gingivalis show evidence of P. gingivalis infiltration, along with various neuropathological hallmarks of AD. Porphyromonas gingivalis (P. gingivalis) and its gingipain virulence factors have been identified as pathogenic effectors in Alzheimer’s disease (AD).
They are Search for dissertations about: "Porphyromonas gingivalis". Showing P. gingivalis produces a variety of virulence factors including gingipains and fimbriae. Duing bacteremia in healthy individuals or patients with chronic periodontitis, a number of oral bacteria such as Porphyromonas gingivalis encounter Gingipain — Gingipain. Gingipaines är proteaser som utsöndras av Porphyromonas gingivalis , speciellt Arg-Gingipain (Gingipain-R, RGP) och I avhandlingsarbetet studerade Eleonor Porphyromonas gingivalis, en patogen som spelar en viktig roll vid utvecklingen av parodontit, men även är kopplad till JHM Levels, P Geurts, H Karlsson, R Marée, S Ljunggren, L Fornander, . Lipoprotein modifications by gingipains of Porphyromonas gingivalis.
Porphyromonas gingivalis (Pg) is a periodontopathic pathogen that may affect MUC5AC‐related mucus hypersecretion along airway epithelial cells. Here, we attempted to establish whether Pg virulence factors (lipopolysaccharide, FimA fimbriae, gingipains) affect MUC5AC in immortalized and primary bronchial cells. Porphyromonas gingivalis is an asaccharolytic, black-pigmented, gram-negative anaerobe that is strongly associated with chronic periodontitis (13), a chronic inflammatory condition affecting tooth-supporting tissues that ultimately results in tooth loss, and may be involved in systemic illnesses, such as atherosclerosis (reviewed in references 28 and 44).
Publications for Helen Karlsson - LiU Electronic Press
Thus, the goal of this study was to determine whether P. gingivalis can promote colorectal cancer progression in vitro. We established an acute infection model Studies have shown that Porphyromonas gingivalis surface structures play an important role in the life cycle of the oral anaerobe. In particular, cysteine proteases, fimbriae, membrane vesicles (MVs), and surface polysaccharides have been of primary interest. Feb 2, 2021 Figure 1Mechanisms Whereby Gingipains and Porphyromonas gingivalis Peptidylarginine Deiminase (PPAD) Promote Disease.
The periodontal pathogen Porphyromonas gingivalis - DiVA
This bacterium appears to migrate from the mouth to the brain of some individuals as they age, and of a significant proportion of subjects who go onto develop Alzheimer’s disease. Porphyromonas gingivalis, a bacterium associated with active chronic periodontitis lesions, produces several proteolytic enzymes that are thought to be involved in host colonization, perturbation of the immune system, and tissue destruction. Porphyromonas gingivalis is an asaccharolytic, black-pigmented, gram-negative anaerobe that is strongly associated with chronic periodontitis (13), a chronic inflammatory condition affecting tooth-supporting tissues that ultimately results in tooth loss, and may be involved in systemic illnesses, such as atherosclerosis (reviewed in references 28 and 44). Porphyromonas gingivalis and its different gingipain variants induced ROS and consumed antioxidants. Both the Rgp and Kgp gingipains were involved in inducing lipid peroxidation. Conclusion. Porphyromonas gingivalis has the potential to change the expression of lipoproteins in blood, which may represent a crucial link between periodontitis and CVD. Peter L.W. Yun, Arthur A. DeCarlo, Cheryl C. Chapple, Charles A. Collyer, Neil Hunter, Binding of Porphyromonas gingivalis gingipains to human CD4+ T cells preferentially down-regulates surface CD2 and CD4 with little affect on co-stimulatory molecule expression, Microbial Pathogenesis, 10.1016/j.micpath.2005.01.001, 38, 2-3, (85-96), (2005).
Porphyromonas gingivalis is a gram-negative, rod-shaped, nonmotile bacterium belonging to the phylum Bacteroidetes. It produces abundant amounts of proteases in both cell-associated and secretory forms, including a group of cysteine proteases referred to as gingipains, which have attracted much attention due to their high proteolytic activity associated with pathogenicity. Gingipains from Porphyromonas gingivalis play a significant role in induction and regulation of CXCL8 in THP-1 cells Jayaprakash, Kartheyaene, 1983- (author) Örebro universitet,Institutionen för hälsovetenskap och medicin
Recently, research has suggested that Alzheimer disease pathology could be driven in part by Porphyromonas gingivalis (P. gingivalis), an infectious agent involved in the development of chronic gum disease. Additionally, the findings showed that inhibiting its protease may be able to treat the neurodegenerative condition.
Agunnaryds lanthandel
Tamotsu Yoshimori. Hiroko Omori. A. Amano. Takafumi Kato.
PY - 2007. Y1 - 2007
Reports suggest the role of Porphyromonas gingivalis specific Arg- and Lys-specific proteinases in the orchestration of the initiation and progression of periodontal diseases.
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Kai Bao - Postdoctoral Researcher - Karolinska Institutet
Role for Gingipains in Porphyromonas gingivalis Traffic to Phagolysosomes and Survival in Human Aortic Endothelial Cells Kumiko Yamatake, 1 Maki Maeda, † Tomoko Kadowaki, Ryosuke Takii, 1 2016-10-20 · The pathogenicity of the periodontal biofilm is highly dependent on a few key species, of which Porphyromonas gingivalis is considered to be one of the most important pathogens.
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Lindmark U, Wagman P, Wåhlin C, Rolander B. Workplace Health in Dental Care. H. Lipoprotein modifications by gingipains of Porphyromonas gingivalis. process: proteinet gingipain från bakterien Porphyromonas gingivalis vissa potentiella markörer som ubiquitin C och gingipains finns oftare av T Honnér — enzymer från bakterier (till exempel trypsinlika proteaser som gingipains R och G) kan bryta De mest studerade är gingipains som utsöndras av P. gingivalis.
Gingipains, a group of arginine or lysine specific cysteine proteinases (also known as RgpA, RgpB and Kgp), have been recognized as major virulence factors in Porphyromonas gingivalis. This bacterium is one of a handful of pathogens that cause chronic periodontitis. Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis.